Parallel World Pharmacy Season 2 release date: Isekai Yakkyoku Season 2 predictions

Isekai Yakkyoku Season 2
It’s predicted that the anime production committee will have Parallel World Pharmacy renewed for a second season. Pic credit: Studio Diomedea

The Parallel World Pharmacy Season 2 anime will have Farma de Medici teaching as a university professor and working with his older brother Palle as cosmic mysteries are investigated. But when will Isekai Pharmacy Season 2 (Isekai Yakkyoku Season 2) come out?

The studio and main staff making Parallel World Pharmacy Season 2 haven’t been announced yet.

For the first season, the anime project was produced by Japanese animation company Studio Diomedea, which in recent years is best known for making The Saint’s Magic Power is Omnipotent, Squid Girl, Aho Girl, Chio’s School RoadDomestic Girlfriend, and Ahiru no Sora.

In the future, it’s been confirmed that The Saint’s Magic Power is Omnipotent Season 2 anime is in production. The Magical Revolution of the Reincarnated Princess and the Genius Young Lady anime release date is in 2023.

The first season of the Parallel World Pharmacy anime project was helmed by director Keizou Kusakawa (Ahiru no Sora, Happy Sugar Life, Aho Girl). My Teen Romantic Comedy SNAFU creator Wataru Watari (The Saint’s Magic Power is Omnipotent, Magical Revolution) handled the scripts and series composition.

Artist Mayuko Matsumoto (Chio’s School Road, animation director for Domestic Girlfriend OP) was the character designer. Composer Tatsuya Katou (Sakugan, Free! series, Food Wars series, Dr. STONE series) created the music.

The Parallel World Pharmacy Season 2 OP (opening) and ED (ending) theme song music hasn’t been announced yet.

For the first season, the Parallel World Pharmacy OP “Musouteki Chronicle” was performed by Kaori Ishihara, while the ED “Hakuu” was performed by Little Black Dress.

TVアニメ『異世界薬局』 ノンクレジットOP
The Isekai Yakkyoku OP trailer video.

The first season of Parallel World Pharmacy was streaming in Summer 2022 with English subtitles on Crunchyroll, VRV, Disney+ Japan, and Netflix Japan (not Netflix USA, Disney+ USA, Hulu, Funimation, or Amazon Prime Video).

The first season’s finale, Parallel World Pharmacy Episode 12, will release on September 25, 2022.

The 12 episodes were released as three Parallel World Pharmacy Blu-Ray/DVD volumes on September 28, 2022, October 26, 2022, and November 25, 2022, respectively.

This article provides everything that is known about Parallel World Pharmacy Season 2 (Isekai Yakkyoku Season 2 / Isekai Pharmacy Season 2) and all related news. As such, this article will be updated over time with news, rumors, and analysis. Meanwhile, let’s delve down into what is known for certain.

Isekai Yakkyoku Season 2 release date predictions: Is renewal likely?

As of the last update, Studio Diomedea, Kadokawa, or any company related to the production of the anime has not officially confirmed the Parallel World Pharmacy Season 2 release date. Nor has the production of an Isekai Yokkyoku Season 2 sequel been announced.

Once the news is officially confirmed this article will be updated with the relevant information.

In the meantime, it’s possible to speculate about when, or if, the Isekai Pharmacy Season 2 release date will occur in the future.

At first glance, the Parallel World Pharmacy anime looks awfully similar to the Drug Store in Another World (Cheat Kusushi no Slow Life: Isekai ni Tsukurou Drugstore) anime that came out in 2021. But watch only one episode and the differences are immediately apparent.

While Isekai Drugstore was mostly slice of life fantasy, Isekai Pharmacy is a character-driven drama. Farma’s story is reminiscent of Myne’s story from Ascendance of a Bookworm. Instead of maintaining a generic isekai vibe, Isekai Pharmacy has the main character reincarnating by imprinting onto an existing person in another world. The central theme story also revolves around knowledge being power rather than Farma simply having all-powerful healing abilities.

The majority of the characters are well-rounded and do not react to Farma in the usual pattern associated with isekai tropes. Amusing yet insightful Eleonore “Elen” Bonnefoi isn’t just a waifu insert, Queen Elizabeth II has depth beyond a monarch, and audiences are given insight into the many sides of Farma’s father beyond the stern paternal demeanor.

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The exception is probably Charlotte “Lotte” Soller since she behaves like many generic isekai harem girls albeit in servant mode. Thankfully, Farma and Lotte’s relationship is always platonic since the story doesn’t force any awkward romance or harem shenanigans that is endemic of most isekai stories. There’s also Farma’s sister, Blanche, but considering her young age it’s forgivable that she’s essentially a little sister trope insert.

What’s more, she’s used as a foil for developing Farma’s feelings of loss regarding his dead sister Chi when he was powerless to save her from the incurable brain tumor as Kanji Yakutani. In that manner, Parallel World Pharmacy is similar to Mushoku Tensei since Farma’s past trauma from his prior life plays a major factor in his character development in this new world similar to Rudeus.

Considering all of these positive storytelling factors, it’s no surprise that the Parallel World Pharmacy review scores are considerably higher than average than almost all of the Summer 2022 isekai anime including Harem in the Labyrinth of Another World, My Isekai Life, and Black Summoner. Isekai Pharmacy even did better than The Devil is a Part-Timer! Season 2! (The Devil is a Part-Timer! Season 3 anime TV show is reportedly already being planned out.)

The major exception is the Overlord anime and the DanMachi anime, but since both are already in their fourth seasons it would have been almost shocking if Isekai Pharmacy had managed to overpower those popular isekai anime. (Overlord Season 5 and DanMachi Season 5 are pretty much inevitable.)

Speaking of popularity, the Parallel World Pharmacy anime was regularly featured in the Top 5 of Crunchyroll’s most popular anime list during Summer 2022. Perhaps some of this popularity can be attributed to HIDIVE stealing away several major Summer 2022 exclusives like Made In Abyss, Call of the Night, Vermeil in Gold, My Isekai Life, and DanMachi. After all, with less competition more Crunchyroll-only subscribers are likely to give time to anime series that would otherwise be lost in the seasonal shuffle.

One negative data point is that the Parallel World Pharmacy manga and light novel series did not make any Top 10 list in July or August 2022 according to Oricon. The only isekai to make those charts was the Overlord light novels, which unsurprisingly dominated the top spot for weeks.

But a large boost in manga and light novel sales is only an indication of popularity in Japan. The deciding factor is the international streaming revenue, which should be good enough.

On the whole, it still seems likely that the anime production committee will have Parallel World Pharmacy renewed for a second season. We’ll just have to wait and see since many isekai anime are receiving sequels.

Parallel World Pharmacy Season 2 English dub release date

Crunchyroll’s Parallel World Pharmacy English dub release date for the first season was on July 24, 2022, which was only several weeks behind the series premiere on July 10, 2022.

Here was Crunchyroll’s Parallel World Pharmacy dub cast:

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Presumably, now that Funimation is being phased out by Sony, Crunchyroll’s Isekai Yakkyoku Season 2 English dub release date will be announced in the future after Isekai Pharmacy Season 2 has first premiered with Japanese audio and English subtitles.

Hopefully, future English dubbing will be faster once the COVID pandemic winds down and becomes endemic. In order to protect voice actors from the impact of the coronavirus pandemic, they were forced to temporarily pause production or take extra safety precautions that resulted in slowed work.

Many English dubbing houses have experienced delays since voice actors often travel to the recording studio. By mid-2022 Crunchyroll began switching from remote recording to in-studio recording again (most of the work is done in their Texas studio).

Parallel World Pharmacy web novel already ended… and it’s in a multiverse!?

The story for the anime TV show is based on the Parallel World Pharmacy light novel series by author Liz Takayama and illustrator keepout. The author is a real-life pharmacist in addition to being a writer.

The Isekai Yokkyoku web novel was initially launched on the self-publishing site Shosetsuka ni Naro back in July 2015. The web novel version ended with Arc 9 on June 15, 2022 (an epilogue was published 2 days later).

Japanese publisher Media Factory’s MF Books imprint began publishing the light novel adaptation in January 2016. As of July 21, 2021, the book series was up to Parallel World Pharmacy Volume 8, which means the series could be ending relatively soon since the light novels are based on a finished web novel.

In November 2016, Takyama teamed up with artist Sei Takano to create the Parallel World Pharmacy manga series. Serialized in Kadokawa Shoten’s ComicWalker magazine, it’s up to Volume 8 as of March 22, 2022.

Unfortunately, no North American publisher has announced an official English translation of the books. However, there are fan translation projects for both the web novel and the manga.

Takayama has created multiple web novel stories, including Invisible (AD 2007), VisibleWorld (AD 2023), Tokyo Inverse (AD 2027), Isekai Pharmacy (AD 20XX), and Heaven’s Under Construction (AD 2133). In 2021, the author revealed that all of his stories are interconnected as part of a science fiction multiverse series.

All of these worlds are being watched by an entity called Observer XERO. In order to grasp the whole picture, it’s recommended that readers start by reading Invisible, which is considered to be Episode 1 in the multiverse collection.

To give an idea of how the stories are interconnected, one of the stories explains what happened to the original consciousness of the 10-year-old boy Farma. Rather than being overwritten or erased, the soul of the original Farma is transmitted into the “past” into the body of 10-year-old Yakutani Kanji! This story takes place in the year 2027 in yet another parallel universe of Japan.

Isekai Yakkyoku Volume 3
It’s predicted that Parallel World Pharmacy Season 2 will pick up the story again in light novel Volume 3. Pic credit: keepout

Parallel World Pharmacy manga, light novels compared to the anime

The Parallel World Pharmacy anime has joined the esteemed ranks of recent adaptations that only adapted a small number of books rather than rushing through the source material. While it’s not quite as good as the 86 anime or The World’s Finest Assassin Gets Reincarnated in Another World as an Aristocrat, Studio Diomedea has been extremely faithful to the heart of the books.

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When a light novel series is condensed down into the TV episodic format it’s unavoidable that worldbuilding narrative and dialogue will be reduced and/or skipped. In this case, the anime needed to skip internal monologues and dialogue that were even in the manga version.

For example, Episode 1 adapted the first two manga chapters but it skipped minor scenes like showing how Farma was struck by lightning while shopping. Farma’s father stopped his cardiac arrest with a potion, which led to Farm critiquing the medical knowledge of this medieval fantasy world. There was a little bit of foreshadowing removed regarding Farma’s divine nature.

By Episode 3, the anime had finished adapting manga Chapter 5. There were multiple changes including the manga changing the narrator’s perspective from Farma to Elen in order to explain the circumstances. The anime made it more clear that if the Empress died from the White Death aka tuberculosis then Farma’s father Bruno would be shamed in the court and might be forced to commit suicide!

Some of the scenes were reordered. Rather than abruptly announcing that he would save the Empress without any planning, the manga had Farma first formulating the drugs in his head and also confirming his diagnosis of bacterial TB with the pocket single lens microscope.

The final scene of Episode 3 also included Bruno’s internal thoughts about Farma, which the manga didn’t provide. As such, the anime actually enhanced the story by focusing on the relationship between father and son.

Episode 4 adapted up through the beginning of manga Chapter 4 and continued the character-driven changes by giving Bruno a flashback scene that wasn’t in the manga. This anime original scene with the man that Bruno saw in prison provided foreshadowing for later events.

Still, the anime did cut corners by removing minor scenes like the microscope being patented and details surrounding the construction of the pharmacy. The anime even skipped a funny scene where Empress Elizabeth realizes just how powerful Farma is due to her staff having a divine arts power meter, so she sends a challenge letter suggesting they duel for the throne once he’s grown strong enough.

Episodes 4 and 5 also added the purple-haired woman Melodie La Roux in various scenes. In the manga, she just popped up whereas the anime introduced her via cameo. Oddly enough, Melodie’s story arc was then skipped.

Episode 7 is where the adaptation pacing began to noticeably increase and the anime began to cut many details from Chapters 13 through 16 (and part of Chapter 19). Some were minor details like the existence of demons, a longer fight with the Inquisitors, Farma’s frightened horse returning to the pharmacy by itself, and how the Inquisitors all tried committing suicide with earth spikes. The anime also skipped actually showing the surgery on Solomon’s leg fracture and how Farma’s original staff broke before he received the powerful medicine god staff the Panac-Rabods.

More importantly, Farma’s brother Palle was supposed to visit from college when Farma was worried about his staff breaking. So the anime shifted things around and removed certain character interactions in order to accelerate the adaptation pacing for the second half of the first season.

Episode 8 then adapted the influenza story arc with Pierre and his daughter Marie. The biggest change from the manga was the addition of the backstory of Guild Boss Veron’s dead child which rounded him out as a more sympathetic villain rather than simply being greedy and suspicious of aristocrats. The anime also skipped a lot of details concerning plans for Farma’s guild and changed how Marie’s medicine had to be delivered via rectal suppository…

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That last scene was cut for many reasons! Not only did poor Marie let out a yelp, but the manga also drew the 7-year-old girl with this horrible expression. It got weird when her father Pierre began ranting about Marie not being able to marry anymore due to losing her purity.

Of course, in the manga, Farma explained that since Marie wasn’t fully conscious ingesting the acetaminophen orally could have caused pulmonary aspiration. Despite the commonality of this medical procedure in modern society, the anime version avoided any controversy about the protagonist sticking pills up a little girl’s butt by simply making it so that she was partially aware and awake.

Episode 9 jumped into the long Black Death story arc. Notably, the Parallel World Pharmacy OP video blatantly teased the Black Death arc so light novel/manga readers knew how the anime would end right away.

As previously noted, the anime skipped adapting the story arc about Baroness Melodie La Roux. This omission was only important since the arc introduced the concept of evil spirits which became important during the Black Death arc. However, since the Inquisition had already established that evil spirits exist it was best that the anime spent its limited screen time on fully developing the Black Death arc.

Episode 9 also spent a little time developing Farma’s brother Palle but the manga and light novels actually had Palle coming home for a visit rather than being stuck at the institute by the lockdown. It was during the home visit that readers learned how Palle was a womanizer and a bully to his two younger siblings. Since Palle plays a major role in Parallel World Pharmacy Season 2 this aspect of his personality will have to be fleshed out by the second season.

Otherwise, the anime adapted all the major parts of the Black Death story arc. One minor change was that the attack of the gate portcullis was shortened. The Holy Knights had to work harder to overcome the defenses and release the white squirrels into the capital city rather than simply busting through with the unexpected magical Divine Arts.

Empress Leeroy Jenkins
The fan translation literally has Farma calling the Empress a Leeroy Jenkins! When Farma’s pharmacy was attacked the hot-headed Empress even wanted to utterly destroy anyone involved, but the anime version of the Empress removed this aspect of her personality and focused on her regal nature. Considering that the Empress’ Divine Art affinity is fire it was disappointing the anime removed her fiery tendencies. Pic credit: keepout

Besides making some changes due to time constraints, the anime was noticeably less lewd in comparison to the manga. For example, Elen fan service moments were cut, including the wet shirt scene on the uninhabited island that was noticeably more suggestive in the manga art.

The anime also skipped an awkward scene where Farma gave his mother a poultice for her lower back pain. In the manga, Lady Beatrice literally stripped down, laid facedown naked on her bed, and began moaning when Farma manually applied it with his hands… Needless to say, Farma is weirded out by this but he manages to maintain his detached medical professionalism.

All in all, it’s predicted that the ending of the first season’s finale, Isekai Yakkoyoku Episode 12, will find a stopping point corresponding to manga Volume 8: Chapter 39 (or light novel Volume 2).

The ending of the black death plague story arc is the best stopping point for the first season. After that, later story arcs start investigating certain cosmic mysteries so that’s best reserved for Parallel World Pharmacy Season 2 so anime-only fans aren’t left hanging wondering what’s really going on.

The good news is that Parallel World Pharmacy Season 2 could be renewed immediately since there is plenty of source material in the light novel series available now.

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The bad news is that the anime almost caught up with the latest manga chapters. Manga readers who wish to read ahead of the anime can jump to Volume 8: Chapter 40.

Isekai Pharmacy Season 2 anime TV spoilers (plot summary/synopsis)

The aftermath of the attack by the evil spirit leaves the Empire shaken but unbroken. A neighboring country is in chaos from the plague so the Empress sends out relief aid. Once a military forward base is established Farma is expected to join the army with a squad of knights. It turns out her majesty had already delayed Farma’s enrollment in the army due to all the hard work he was doing in the Capital and Marseille.

Having saved the Imperial City from the Black Death, Farma is visited by pharmacists from the Apothecary guild who wish to sell Farma’s new medicine. No one is willing to buy the old remedies since it’s known they don’t work and the guild pharmacies are in danger of bankruptcy. With the old system collapsing, the younger pharmacists are willing to break old traditions, especially since the stubborn older generation of guild leaders refused Farma’s plague cure and then died!

Additionally, Farma is invited to teach at the San Fleuve Imperial School of Pharmacy as a senior professor. Just like in his old life, Farma is in danger of overworking since he’s expected to be a part-time university professor while also inspecting the completed pharmaceutical factory.

Bruno is pushing Farma to research and bring many new drugs into the world since ancient texts claim that Farma’s special divine revelation is temporary. It’s possible Farma as he is now will eventually disappear from this world so Bruno wishes for Farma to leave behind a legacy of excellence.

Bruno wants bigger work for Farma, but all that does is remind him of overworking himself to death (or karoshi). At this point, all poor Farma wants is to take a relaxing dip in a hot spring. But even that seemingly innocent goal leads to more stress.

Meanwhile, Farma’s brother Palle has graduated at the top of his class from the college of medicine and returned to his family. But somehow he’s never been told that his younger brother is the proprietor of the Parallel World Pharmacy!

Farma breaks out into a cold sweat when Palle unexpectedly shows up at his pharmacy expecting to be a patient. Palle had been lining up before that pharmacy opened and he was suffering from an unexplained medical malady that only Farma’s special eye could see.

Farma succeeds in rescuing his brother Palle, who was suffering from leukemia, from the brink of death by making full use of his knowledge of modern medicine and the power of a secret treasure. But when Palle and Farma work together on writing textbooks for the Imperial College of Medicine Palle begins to suspect that his younger brother’s knowledge is rooted in another world.

In the midst of all this, Farma becomes suspicious when Bishop Solomon abruptly disappears after months of regular visits to the pharmacy. When Farma goes to rescue Solomon, Farma obtains an enshrined treasure that turns out to be a university staff card from Farma’s previous life… but it’s no longer just a card!?

With Parallel World Pharmacy Season 2 we enter… the multiverse! The Marvel Cinematic Universe has made the concept popular and the major plot twist in Isekai Pharmacy is the revelation of these cosmic mysteries.

Unfortunately, anime fans will have to wait until the Parallel World Pharmacy Season 2 release date to watch what happens next. Stay tuned!

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